Spinnen des Todes (2001)

earth vs. the spider is a terrifying horror thriller starring dan aykroyd (pearl harbor), theresa russell (wild things), devon gummersall (independence day) and amelia heinle (the limey) and features special effects by the four-time academy award-winning monster-maker stan winston (jurassic park 3, artificial intelligence, aliens).
quentin is a nerdy comic book fanatic who spends his days working as a security guard at a biotech research lab and his nights at home dreaming of superheroes. when thugs ambush the lab, his partner is killed in the shootout. overcome by grief, he knowingly injects himself with a top-secret drug made from the blood of a laboratory spider. slowly, the effects of the injection change his body - and as quentin becomes more like a spider and less like a human, he develops a hunger that will not be ignored.